概述

平滑肌肉瘤是一种罕见的癌症,始于平滑肌组织。平滑肌组织存在于身体的许多部位,如消化系统、泌尿系统、血管和子宫。

平滑肌肉瘤最常发于腹部或子宫,起初表现为异常细胞的生长,它们通常生长迅速,会侵入并破坏正常的身体组织。

平滑肌肉瘤的体征和症状取决于肿瘤的位置,可能包括疼痛、体重减轻,以及可以通过皮肤摸到的肿块或肿胀。

平滑肌肉瘤是一种软组织肉瘤,是一个大的癌症类别,通常形成于连接、支撑和围绕其他身体结构的组织中。

Types

症状

Leiomyosarcoma might not cause signs or symptoms at first. As the cancer grows, symptoms may include:

  • Pain.
  • Weight loss.
  • Nausea and vomiting.
  • A lump or swelling under the skin.

When to see a doctor

Make an appointment with a doctor or other healthcare professional if you have symptoms that worry you.

病因

It's not clear what causes leiomyosarcoma. This cancer starts when something changes the cells in the smooth muscles. Many areas of the body have smooth muscle tissue. These include the digestive system, urinary system, blood vessels and uterus.

Leiomyosarcoma happens when smooth muscle cells develop changes in their DNA. A cell's DNA holds the instructions that tell the cell what to do. In healthy cells, the DNA tells the cells to grow and multiply at a set rate. The DNA also tells the cells to die at a set time.

In cancer cells, the DNA changes give other instructions. The changes tell the cancer cells to grow and multiply at a fast rate. Cancer cells can keep living when healthy cells would die. This causes too many cells.

The cancer cells might form a mass called a tumor. The tumor can grow to invade and destroy healthy body tissue. In time, cancer cells can break away and spread to other parts of the body. When cancer spreads, it's called metastatic cancer.

风险因素

Risk factors for leiomyosarcoma include:

  • Being an adult. Leiomyosarcoma can happen at any age. But it is most common in adults. It's rare in children.
  • Having certain genetic conditions. People with certain genetic conditions may have a higher risk of leiomyosarcoma. These conditions include hereditary retinoblastoma and Li-Fraumeni syndrome.

Healthcare professionals haven't found a way to prevent leiomyosarcoma.

Dec. 04, 2024

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  1. Leiomyosarcoma. National Cancer Institute. https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-soft-tissue-tumors/leiomyosarcoma. Accessed March 17, 2021.
  2. Goldblum JR, et al. Leiomyosarcoma. In: Enzinger and Weiss's Soft Tissue Tumors. 7th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed March 17, 2021.
  3. Soft tissue sarcoma. National Comprehensive Cancer Network. https://www.nccn.org/professionals/physician_gls/default.aspx. Accessed March 17, 2021.