Clinical Trials A continuación, se enumeran los ensayos clínicos actuales.79 estudios en Digestive Diseases (solo estudios abiertos). Filtra esta lista de estudios por sede, estado, etc. A Study to Assess Clonal Diversity of Freshly Taken ESD Specimens Rochester, Minn. Inclusion Criteria: Patients with Barrett’s Esophagus (BE) or Esophageal Adenocarcinoma (EAC) that are planned for Endoscopic Submucosal Dissection (ESD) treatment. Exclusion Criteria: Patients without BE or EAC or that are not planned for ESD treatment. Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma Rochester, Minn., Mankato, Minn., La Crosse, Wis., Jacksonville, Fla., Eau Claire, Wis., Austin, Minn., Scottsdale/Phoenix, Ariz. This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease. A Study to Develop a Biorepository of Blood Samples from Cancer Patients Participating in the Gemini (IRB 19-006717) Protocol Jacksonville, Fla., Scottsdale/Phoenix, Ariz. The purpose of this study is to develop a biorepository of blood samples from cancer patients participating in the Gemini (IRB 19-006717) protocol. These samples will be used for future biomarker discovery and other translational studies. Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers Rochester, Minn. A Phase 1b/2, open label, multi-center, clinical study of Chimeric Antigen Receptor T Cells (CAR-T) targeting claudin18.2 in patients with advanced gastric, pancreatic or other specified digestive system cancers. In-home Versus In-Clinic Subcutaneous Nivolumab Administration through Connected and Remote Cancer CARE Beyond Walls Jacksonville, Fla. The purpose of this study is to evaluate the impact of the location of SQ Nivo administration, at the infusion center or in the home, on patient preference and acceptability, safety, patient reported outcomes (PROs), and clinical outcomes. Detection of Plasma DNA Methylation in Peripheral Blood from Patients with Hepatocellular Carcinoma Rochester, Minn. This study aims to investigate the utility of using plasma DNA methylation to detect measurable residual disease or early recurrence/progression of patients with hepatocellular carcinoma. Symptoms During a Gastric Emptying Study Rochester, Minn. To understand the utility of measuring stomach emptying, symptoms during a stomach emptying, and blood markers of body metabolism. Influence of Diet on Tissue and Body Fluids in Health and Disease Scottsdale/Phoenix, Ariz. This study aims to compare the fatty acid composition of small sample of fat (visceral and subcutaneous) removed at the time of surgery to operative outcomes and the composition calculated from the person’s dietary history and preoperative imaging with MRI/CT scans. This study will also compare the composition of pancreatic fluid collected to that of a sample of fat removed at the time of surgery to drain the collection. Furthermore, we will study the fatty acid composition of drain fluid placed at the time of surgery to that of their fat samples. SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study Rochester, Minn. The purpose of this interventional study is to test and compare the effectiveness of two elimination diets—the 1-food elimination diet (1FED, milk only) and the 6-food elimination diet (6FED, milk, egg, wheat, soy, tree nut/peanuts, and fish/shellfish). The study will also test the effectiveness of swallowed glucocorticoid therapy in some of the study participants for whom diet therapy was not effective. The Olmsted NAFLD Epidemiology Study (TONES) Rochester, Minn. About this study Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world and a major public health issue in the US. It is estimated to affect 1 in 4 adults and it is most commonly found in people who are overweight or obese. Because it is a silent disease (without symptoms until end stage) and the lab tests can be normal, it can be missed in early stages. The fat in the liver can lead to inflammation and eventually scar deposition, which can progress to cirrhosis, liver cancer and need for liver transplantation. This study aims to assess how common this disease is in Olmsted County, what markers can identify the disease early to prevent progression to cirrhosis and what other medical problems occur in people with NAFLD in addition to the liver complications. We plan to enroll a large number of adults, assess their liver with state-of-the-art tests available at Mayo Clinic and follow them over several years to monitor for disease progression and other health complications. The ultimate goal of the study is to identify new markers that predict presence of fatty liver and poor health outcomes, in order to improve population health in the community. Participation eligibility Participants will be identified from the Olmsted County population age 18 or older. Inclusion criteria: 1. Adults age 18 years or older 2. Olmsted County residents at the time of study entry Exclusion criteria: 1. Pediatric population (age<18) 2. Unwilling to participate or unable to consent 3. Known liver disease other than NAFLD at the time of survey 4. Pregnant women 5. Alcohol use in excess (14 drinks or more per week for women and 21 drinks or more per week for men) Numeración de páginas Estudios clínicos AnteriorPágina anterior Ir a página 55 Ir a página 66 Ir a página 77 Ir a página 88 SiguientePróxima página Profesionales médicos Digestive Diseases clinical-trials