Regadenoson (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of regadenoson injection in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of regadenoson injection in the elderly. However, elderly patients are more likely to have low blood pressure, which may require caution in patients receiving regadenoson injection.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aminophylline
• Bamifylline
• Dimenhydrinate
• Dyphylline
• Pentoxifylline
• Theophylline

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina, unstable or
• Unstable heart or blood vessel problem (eg, cardiovascular instability)—Avoid use, as this drug may increase the risk for heart attack.

• Breathing problems or lung disease (eg, asthma, bronchoconstriction, COPD) or
• Heart rhythm problems (eg, atrial fibrillation, atrial flutter) or
• Hypertension (high blood pressure) or
• Hypotension (low blood pressure) or
• Seizures or
• Stroke, history of—Use with caution. May make these conditions worse.

• Heart block, second or third degree (type of abnormal heart rhythm), without a pacemaker or
• Sinus node dysfunction (type of abnormal heart rhythm), without a pacemaker—Should not be used in patients with these conditions, unless patients have a pacemaker that works.

• Heart or blood vessel disease (eg, coronary artery stenosis, ischemia, pericarditis) or
• Heart valve disease or
• Hypovolemia (low blood volume)—May increase risk for more serious side effects.

More common

• Arm, back, or jaw pain
• chest pain or discomfort
• difficult or labored breathing
• fast or irregular heartbeat
• nausea
• sweating
• tightness in the chest

Incidence not known

• Confusion
• difficulty swallowing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fainting
• irregular heartbeat recurrent
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rash, hives, or itching skin
• trembling or shaking of the hands or feet
• unusual tiredness or weakness

Symptoms of overdose

• Dizziness
• feeling of warmth
• increased heart rate
• redness of the face, neck, arms, and occasionally, upper chest

More common

• Headache

Less common

• Change in taste
• loss of taste
• stomach soreness or discomfort

Incidence not known

• Diarrhea
• difficulty with moving
• joint pain
• muscle aching or cramping