Anidulafungin (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of anidulafungin injection in children younger than 1 month of age with candidemia or candida peritonitis and abscess. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of anidulafungin injection in children with esophageal candidiasis. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anidulafungin injection in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Levoketoconazole
• Methotrexate

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergies to other echinocandin antifungal drugs (eg, caspofungin [Cancidas®], micafungin [Mycamine®])—Should not be used in patients with this condition.

• Fructose intolerance (rare hereditary problem)—Should not be used in patients with this condition.

• Liver disease—Use with caution. May make this condition worse.

Less common

• Black, tarry stools
• chills
• cough
• decreased urine
• dry mouth
• fever
• increased thirst
• irregular heartbeat
• loss of appetite
• lower back or side pain
• mood or mental changes
• muscle pain or cramps
• nausea
• numbness or tingling in the hands, feet or lips
• painful or difficult urination
• pale skin
• seizures
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting

Rare

• Back pain
• bleeding gums
• blood in the urine or stools
• bloody stools
• bluish color of skin
• blurred or loss of vision
• changes in skin color
• chest pain or tightness
• clay-colored stools
• constipation
• dark urine
• depression
• diarrhea
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• extra heartbeats
• fainting
• fast heartbeat
• flushed, dry skin
• flushing
• fruit-like breath odor
• headache
• hives or welts
• incoherent speech
• increased hunger
• increased urination
• irregular fast heartbeat
• irritability
• itching
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• light-colored stools
• metallic taste
• muscle spasms (tetany) or twitching
• muscle weakness
• nervousness
• pain, redness, or swelling in the arm or leg
• pain, tenderness, and swelling of foot or leg
• pinpoint red spots on the skin
• pounding in the ears
• redness of the skin
• restlessness
• skin rash
• slow heartbeat
• sore mouth or tongue
• stomach pain
• sweating
• swelling of the feet or lower legs
• swollen glands
• trembling
• unexplained weight loss
• unpleasant breath odor
• unusually warm skin
• vomiting of blood
• weakness
• weight loss
• white patches in the mouth or throat or on the tongue
• white patches with diaper rash
• yellow eyes or skin

Rare

• Acid or sour stomach
• belching
• bloating or swelling of the face, arms, hands, lower legs, or feet
• disturbed color perception
• double vision
• eye pain
• feeling of warmth
• feeling unusually cold
• halos around light
• indigestion
• loss of bowel control
• night blindness
• over bright appearance of lights
• rapid weight gain
• redness of the face, neck, arms, and occasionally, upper chest
• shivering
• stomach discomfort or upset
• tingling of the hands or feet
• tunnel vision
• unusual weight gain or loss